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The hypothalamus directs the pituitary gland (located at the base of the brain) to produce ACTH (adrenocorticotrophic hormone).
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YES
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This hormone is released into the bloodstream and stimulates the body's two adrenal glands (located near the kidneys) to secrete glucocorticoid (cortisol) hormones into the bloodstream.
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YES
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Cortisol helps the body respond to stress.
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YES
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Impacts blood sugar levels,
fat metabolism,
skeletal muscles,
kidney function,
nervous system,
cardiovascular system,
immune response
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YES
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Cortisol secretion is increased due to stress, infection, pain, surgery, trauma, cold temperatures.
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YES
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When cortisol levels are high enough, the pituitary stops secreting it.
When cortisol levels dip low enough, the pituitary secretes more.
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YES
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The adrenals respond by secreting glucocorticoid hormones in response to the pituitary, just as the pituitary responds by secreting ACTH in response to the adrenals. The net effect is that a mildly fluctuating balance is achieved.
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YES
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In Cushings Disease something goes wrong with this process for one of three reasons:
a pituitary tumour
an adrenal tumour
steroid use over a long period of time
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Cushings Flowchart
More flowcharts
