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COPD                       EXACERBATION/ FLARE UP         EXCESS MUCUS PRODUCTION SOB DOE     INCREASE COUGH, FLU ABNORMAL GAS EXCHANGE       AIRWAY IRRITANTS DESTRUCTION OF ALVEOLI     INCREASE GOBLET CELLS INCREASE SUBMUCOSAL GLAND HYPOXEMIA HYPERCAPNIA   OBSTRUCTED AIRWAY INCREASE MUCUS PRODUCTION RESPIRATORY ACIDOSIS HYPOXIA   INCREASE BACTERIA LUNG INFECTION   CYANOSIS